This billboard is the only digital face along I-64/40 within the St. Louis City limits. This Interstate is the most heavily traveled thoroughfare in the city that connects Missouri to Illinois, the downtown St. Louis area to St. Louis County, MO, and to St. Charles County, MO. 375AD is a right-hand read traveling eastbound into downtown St. Louis and toward Illinois.
This sign is near the headquarters of Wells Fargo Advisors, Peabody Coal, Ralcorp, AB-InBev, the Cortex Innovation Community, and the soon to be completed National Geospatial Intelligence Agency headquarters.
The St. Louis Cardinals, St. Louis Blues and new Major League Soccer Team, St. Louis City all play downtown with stadiums near this structure. Other nearby attractions and cultural institutions include St. Louis Union Station & Aquarium, the Gateway Arch, and the St. Louis Foundry. Along I-64/40 is Forest Park which contains the St. Louis Zoo, Science Center, Art Museum, History Museum and The Muny. The higher education institutions of St. Louis University, Washington University, and Harris Stowe State University are all located near this digital display. Also nearby are the SSM-St. Louis University Hospital and BJC Healthcare campuses.